Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.59 |
| ▸ | DRD3 | P35462 | 5/20 | 0.59 |
| ▸ | DRD4 | P21917 | 4/20 | 0.59 |
| ▸ | DRD1 | P21728 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | DRD5 | P21918 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335087 | 0.86 | DRD2 (0.64) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7327260 | 0.80 | DRD2 (0.64) | DRD2DRD3DRD4DRD1HTR1A | |
| Hydrochloric Acid SCHEMBL7334103 | 0.79 | DRD2 (0.66) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7331703 | 0.79 | DRD2 (0.61) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7334180 | 0.79 | DRD2 (0.67) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7328609 | 0.79 | DRD2 (0.62) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7328876 | 0.78 | DRD2 (0.59) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7331288 | 0.77 | DRD2 (0.61) | DRD2DRD3DRD4DRD1HTR1A | |
| Hydrochloric Acid SCHEMBL7336566 | 0.77 | DRD2 (0.66) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL7335448 | 0.76 | DRD2 (0.68) | DRD2DRD3DRD4DRD1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |