Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.68 |
| ▸ | DRD3 | P35462 | 4/20 | 0.68 |
| ▸ | DRD4 | P21917 | 3/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.68 |
| ▸ | DRD5 | P21918 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 1/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763436 | 0.90 | HTR1A (0.68) | DRD2DRD3HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL8822572 | 0.89 | HTR1A (0.67) | DRD2DRD3HTR1AHTR7 | |
| SCHEMBL7335087 | 0.81 | DRD2 (0.64) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL7330393 | 0.81 | DRD2 (0.64) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL7327260 | 0.81 | DRD2 (0.64) | DRD2DRD3DRD4HTR1ADRD1 | |
| 5-Oh-Dpat SCHEMBL17446178 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| 5-Oh-Dpat SCHEMBL279021 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| 5-Oh-Dpat SCHEMBL29420186 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| 5-Oh-Dpat SCHEMBL5705486 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| 5-Oh-Dpat SCHEMBL30201073 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |