Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328555 | 0.92 | KDM4E (0.46) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| Oxalic Acid SCHEMBL7331859 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL4321291 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1HCRTR1HPGD | |
| SCHEMBL2791825 | 0.73 | HCRTR1 (0.51) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL4156097 | 0.72 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2HCRTR1HPGD | |
| SCHEMBL7321450 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2POLBHCRTR1 | |
| Oxalic Acid SCHEMBL7320960 | 0.70 | S1PR1 (0.51) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| Oxalic Acid SCHEMBL7320957 | 0.70 | S1PR1 (0.51) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL5442983 | 0.69 | HTR3E (0.46) | ALDH1A1LMNA | |
| SCHEMBL5442986 | 0.69 | HTR3E (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |