Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328005 | 0.91 | NPC1 (0.37) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL7325553 | 0.80 | HTR3A (0.47) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL9050935 | 0.77 | HTR3A (0.48) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL6851022 | 0.73 | ADRA1A (0.53) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9050185 | 0.73 | KMT2A (0.52) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL7327993 | 0.73 | HTR3A (0.50) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL7327570 | 0.73 | MAPT (0.46) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL6851011 | 0.73 | HTR3A (0.52) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9048823 | 0.72 | GSK3A (0.47) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL7333796 | 0.72 | ADRA1A (0.47) | HTR3AADRA2AADRA2BADRA2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |