Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.65 |
| ▸ | DRD3 | P35462 | 12/20 | 0.65 |
| ▸ | DRD4 | P21917 | 4/20 | 0.65 |
| ▸ | HTR1D | P28221 | 5/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7329618 | 0.99 | DRD2 (0.64) | DRD2DRD3DRD4HTR1DMTNR1A | |
| Hydrochloric Acid SCHEMBL7336043 | 0.92 | DRD2 (0.62) | DRD2DRD3DRD4HTR1DMTNR1A | |
| SCHEMBL9186494 | 0.90 | DRD2 (0.55) | DRD2DRD3DRD4HTR1DMTNR1A | |
| SCHEMBL7336034 | 0.90 | DRD2 (0.57) | DRD2DRD3DRD4HTR1DMTNR1A | |
| Hydrochloric Acid SCHEMBL7334747 | 0.89 | DRD2 (0.56) | DRD2DRD3DRD4HTR1DMTNR1A | |
| SCHEMBL7327888 | 0.86 | GRIN2B (0.58) | DRD2DRD3DRD4KMT2ASLC18A3 | |
| Hydrochloric Acid SCHEMBL7335303 | 0.85 | GRIN2B (0.57) | DRD2DRD3DRD4KMT2ASLC18A3 | |
| Hydrochloric Acid SCHEMBL7334442 | 0.84 | MTNR1A (0.46) | DRD2DRD3DRD4HTR1DMTNR1A | |
| SCHEMBL7326879 | 0.84 | GRIN2B (0.60) | DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7334214 | 0.83 | GRIN2B (0.46) | DRD2DRD3DRD4HTR1DMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |