Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418021 | 0.98 | PDE4B (0.48) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7327833 | 0.98 | PDE4B (0.48) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7359484 | 0.95 | PDE4B (0.49) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL22988062 | 0.86 | PDE4B (0.49) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1198333 | 0.86 | PDE4B (0.49) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14040698 | 0.83 | CTSK (0.57) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27605899 | 0.79 | KMT2A (0.51) | CTSLPDE4BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7320268 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTTCYP2C19 | |
| SCHEMBL4081547 | 0.78 | NAAA (0.61) | CTSLNAAA | |
| SCHEMBL10719082 | 0.78 | NAAA (0.61) | CTSLNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527761-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | Beecham Group p.l.c. (GB) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991015506-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-10-17 | — | — | WO | disclosed |