SCHEMBL7328580

SCHEMBL7328580

Nc1ccccc1[CH]c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.43
CYP3A4 P08684 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ALDH1A1 P00352 4/20 0.42
HSD17B10 Q99714 1/20 0.42
MAOB P27338 3/20 0.41
CYP19A1 P11511 2/20 0.41
MAOA P21397 2/20 0.41
MAPT P10636 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
TRPA1 O75762 1/20 0.37
NFE2L2 Q16236 1/20 0.37
TSHR P16473 4/20 0.36
CYP2A6 P11509 1/20 0.36
LMNA P02545 1/20 0.35
KDM1A O60341 2/20 0.34
HSP90AA1 P07900 1/20 0.34
NTSR1 P30989 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2494469 0.84 CYP3A4 (0.53) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL28876217 0.82 NFE2L2 (0.47) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL8416900 0.81 ALDH1A1 (0.45) SMN1; SMN2ALDH1A1MAOBCYP19A1MAOA
SCHEMBL911942 0.78 MAOB (0.56) ALDH1A1MAOBCYP19A1MAOAMAPT
SCHEMBL5431188 0.78 MAOB (0.56) ALDH1A1MAOBCYP19A1MAOAMAPT
SCHEMBL3885086 0.78 MAOB (0.56) ALDH1A1MAOBCYP19A1MAOAMAPT
SCHEMBL29397541 0.78 MAOB (0.56) ALDH1A1MAOBCYP19A1MAOAMAPT
SCHEMBL5252489 0.78 CYP19A1 (0.45) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL10701354 0.76 MAOB (0.54) ALDH1A1MAOBCYP19A1MAOAMAPT
SCHEMBL6664801 0.73 LMNA (0.62) CYP3A4SMN1; SMN2ALDH1A1MAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999032428-A2 SYNTHESIS OF DIAMINES INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (IT) 1999-07-01 WO claimed
CN-104892545-B Method for synthesizing poly-substituted 2-aryl benzothiazoles by utilizing thiourea as sulphur source 南京理工大学 2017-02-01 CN disclosed
US-6048863-A SEXUAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-04-11 US disclosed
US-5976544-A Polypeptides and vaccines for Bordetellapertussis and method of use MEDEVA PHARMA LIMITED (GB) 1999-11-02 US disclosed
US-5580855-A ANALGESICS BRITISH TECHNOLOGY GROUP LIMITED (GB) 1996-12-03 US disclosed
EP-0335662-B1 Peptides BRITISH TECH GROUP (GB) 1995-07-26 EP disclosed
EP-0425082-B1 Bordetella vaccines WELLCOME FOUND (GB) 1995-04-26 EP disclosed
US-5389615-A Analgesics BRITISH TECHNOLOGY GROUP LTD. (GB) 1995-02-14 US disclosed
EP-0425082-A1 Bordetella vaccines EVANS MEDICAL LIMITED (GB) 1991-05-02 EP disclosed
WO-1991003255-A1 POLYPEPTIDE VACCINES AGAINST FOOT-AND-MOUTH DISEASE VIRUS THE WELLCOME FOUNDATION LIMITED (GB) 1991-03-21 WO disclosed
EP-0371817-A2 Peptides THE WELLCOME FOUNDATION LIMITED (GB) 1990-06-06 EP disclosed
EP-0371818-A2 Peptides THE WELLCOME FOUNDATION LIMITED (GB) 1990-06-06 EP disclosed
WO-1989009226-A1 PEPTIDES NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1989-10-05 WO disclosed
EP-0335662-A1 Peptides BTG INTERNATIONAL LIMITED (GB) 1989-10-04 EP disclosed