Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394022 | 0.81 | OPRK1 (0.68) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL7328677 | 0.79 | LMNA (0.47) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL8722163 | 0.74 | LMNA (0.60) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL2929249 | 0.72 | LMNA (0.64) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL3783696 | 0.72 | LMNA (0.64) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL4424339 | 0.71 | GABRA1 (0.66) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL11389231 | 0.71 | LMNA (0.62) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL7091758 | 0.71 | GABRA1 (0.66) | LMNAOPRK1PDE3ABRD4BRD2 | |
| SCHEMBL11394894 | 0.71 | LMNA (0.67) | LMNACCKBRHPGDPDE4DGABRA1 | |
| SCHEMBL11925028 | 0.70 | LMNA (0.74) | LMNAOPRK1CCKBRHPGDPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4388313-A | Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof | GEROT-PHARMAZEUTIKA GESELLSCHAFT M.B.H. (AT) | 1983-06-14 | — | — | US | claimed |
| US-4388313-A | Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof | GEROT-PHARMAZEUTIKA GESELLSCHAFT M.B.H. (AT) | 1983-06-14 | — | — | US | disclosed |