Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326818 | 0.84 | CYP1A2 (0.56) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL7324339 | 0.81 | PPARG (0.54) | SMN1; SMN2EPHX2PPARGALDH1A1MMP8 | |
| SCHEMBL10521821 | 0.79 | MMP8 (0.61) | LMNASMN1; SMN2EPHX2PPARGALDH1A1 | |
| SCHEMBL7141032 | 0.77 | CYP1A2 (0.58) | SMN1; SMN2EPHX2PPARGALDH1A1MMP8 | |
| SCHEMBL7369170 | 0.76 | EPHX2 (0.49) | EPHX2PPARGMMP8PKMMAPT | |
| SCHEMBL1127424 | 0.76 | MEN1 (0.57) | LMNASMN1; SMN2EPHX2PPARGALDH1A1 | |
| SCHEMBL7334986 | 0.76 | PPARG (0.50) | SMN1; SMN2EPHX2PPARGALDH1A1MMP8 | |
| SCHEMBL3504311 | 0.76 | EPHX2 (0.70) | EPHX2PPARGMMP8KMT2AMEN1 | |
| SCHEMBL15479082 | 0.76 | PPARG (0.58) | EPHX2PPARGALDH1A1MMP8KMT2A | |
| SCHEMBL7333448 | 0.75 | PKM (0.45) | LMNASMN1; SMN2EPHX2PPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |