Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328953 | 0.94 | DRD4 (0.57) | DRD4EPHA2KDREPHB4ERBB2 | |
| Oxalic Acid SCHEMBL7327776 | 0.85 | DRD4 (0.57) | DRD4KDM4EHRH3 | |
| Oxalic Acid SCHEMBL9368451 | 0.83 | KDM4E (0.55) | KDM4ESMN1; SMN2ALDH1A1POLBMEN1 | |
| Oxalic Acid SCHEMBL9697739 | 0.77 | KDM4E (0.63) | KDM4ESMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL27991036 | 0.76 | DRD4 (0.62) | DRD4HRH3 | |
| SCHEMBL9696871 | 0.76 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1POLBHRH3 | |
| SCHEMBL9370762 | 0.76 | KDM4E (0.51) | DRD4KDM4ESMN1; SMN2ALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL27357671 | 0.75 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1POLBHRH3 | |
| Oxalic Acid SCHEMBL7087974 | 0.74 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1POLBMEN1 | |
| Oxalic Acid SCHEMBL6992880 | 0.74 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |