Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843799 | 0.91 | TDP1 (0.58) | TDP1L3MBTL1HDAC1HDAC7MME | |
| Leucine SCHEMBL8524451 | 0.90 | MMP1 (0.47) | TDP1L3MBTL1MMP1MMP9MMP3 | |
| SCHEMBL12087999 | 0.83 | CYP3A4 (0.53) | TDP1L3MBTL1HDAC1HDAC7 | |
| SCHEMBL12088102 | 0.82 | SIRT2 (0.53) | TDP1L3MBTL1HDAC1HDAC7ACHE | |
| Leucine SCHEMBL6412363 | 0.81 | MMP1 (0.53) | TDP1L3MBTL1HDAC1HDAC7MMP1 | |
| SCHEMBL2004222 | 0.79 | CYP3A4 (0.53) | MMP9MMP3 | |
| SCHEMBL8968592 | 0.79 | CYP3A4 (0.53) | MMP9MMP3 | |
| SCHEMBL7432462 | 0.77 | MME (0.68) | MMEACE | |
| SCHEMBL8491963 | 0.76 | L3MBTL1 (0.48) | TDP1L3MBTL1HDAC1HDAC7CASP3 | |
| SCHEMBL6578347 | 0.76 | TDP1 (0.51) | TDP1L3MBTL1HDAC1HDAC7CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932551-A | INHIBITORS OF MATRIX METALLOENDOPROTEINASE-MEDIATED DISEASES | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0586537-A4 | SUBSTITUTED N-CARBOXYALKYLPEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO INC (US) | 1997-06-25 | — | — | EP | disclosed |
| EP-0586537-A1 | SUBSTITUTED N-CARBOXYALKYLPEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO. INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021360-A1 | SUBSTITUTED N-CARBOXYALKYLPEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO., INC. (US) | 1992-12-10 | — | — | WO | disclosed |