Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | NPY4R | P50391 | 12/20 | 0.37 |
| ▸ | NPY1R | P25929 | 9/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.37 |
| ▸ | NPY2R | P49146 | 5/20 | 0.37 |
| ▸ | GNPAT | O15228 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560458 | 0.89 | CPB2 (0.41) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL9068939 | 0.85 | NPY4R (0.43) | MMEFOLH1NPY4RNPY1RNPY5R | |
| SCHEMBL24805410 | 0.83 | NPY4R (0.40) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL7323579 | 0.82 | ACE (0.44) | ACE | |
| SCHEMBL9068526 | 0.82 | NPY4R (0.40) | MMEFOLH1NPY4RNPY1RNPY5R | |
| SCHEMBL17104378 | 0.82 | NPY4R (0.42) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL17104376 | 0.82 | NPY4R (0.42) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL9069166 | 0.81 | NPY4R (0.43) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL31454130 | 0.80 | NOD1 (0.52) | FOLH1NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL5598692 | 0.80 | NOD1 (0.52) | FOLH1NPY4RNPY1RNPY5RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474795-A | ANALGESICS, MERCAPTO-ALKANOYL AMINO ACIDS | E. R. SQUIBB & SONS, INC. (US) | 1984-10-02 | — | — | US | disclosed |
| US-4474799-A | Enkephalinase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1984-10-02 | — | — | US | disclosed |
| US-4401677-A | Enkephalinase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1983-08-30 | — | — | US | disclosed |