Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 7/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325697 | 0.78 | TP53 (0.41) | CNR2CNR1MAPTKDM4EALDH1A1 | |
| SCHEMBL3899250 | 0.75 | CNR2 (0.59) | CNR2CNR1 | |
| SCHEMBL9531310 | 0.74 | CHRNA7 (0.51) | HTR4 | |
| SCHEMBL7394879 | 0.74 | KDM4E (0.52) | CNR2CNR1KDM4EMEN1ALDH1A1 | |
| SCHEMBL3901927 | 0.73 | CNR2 (0.57) | CNR2CNR1GUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL9531740 | 0.73 | CHRNA7 (0.50) | HTR4 | |
| SCHEMBL4498121 | 0.71 | MAPT (0.63) | CNR2MAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL9532171 | 0.69 | HTR4 (0.59) | KDM4EALDH1A1HTR4CYP3A4CYP2D6 | |
| SCHEMBL13578376 | 0.68 | CNR2 (0.61) | CNR2CNR1 | |
| SCHEMBL4331158 | 0.67 | CNR2 (0.42) | CNR2CNR1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5234921-A | Antagonists of the serotonin 5-HT3 receptor; gastrointestinal disorders; antidepressants; drug abuse | G. D. SEARLE & CO. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5137893-A | Anxilytic agents; antidepressants; antiemetics | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |