Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 15/20 | 0.38 |
| ▸ | CNR1 | P21554 | 6/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329253 | 0.78 | CNR2 (0.45) | TP53CNR2CNR1KDM4EALDH1A1 | |
| SCHEMBL1761845 | 0.75 | ADRA2A (0.45) | TP53CNR2CNR1 | |
| Hydrochloric Acid SCHEMBL9684524 | 0.74 | ADRA2A (0.44) | TP53CNR2CNR1 | |
| Hydrochloric Acid SCHEMBL9684279 | 0.74 | ADRA2A (0.44) | TP53CNR2CNR1 | |
| SCHEMBL9531570 | 0.74 | CHRNA7 (0.52) | — | |
| SCHEMBL9531411 | 0.70 | HTR3E (0.41) | TP53 | |
| SCHEMBL4705312 | 0.70 | FNTA (0.55) | TP53FNTAFNTBKDM4EALDH1A1 | |
| SCHEMBL7362659 | 0.69 | HCN4 (0.53) | TP53KDM4EGAAMAPTTHRB | |
| SCHEMBL9533778 | 0.68 | HTR3A (0.57) | ALDH1A1 | |
| SCHEMBL7373238 | 0.65 | MAPT (0.42) | TP53FNTAFNTBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5234921-A | Antagonists of the serotonin 5-HT3 receptor; gastrointestinal disorders; antidepressants; drug abuse | G. D. SEARLE & CO. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5196547-A | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof | G. D. SEARLE & CO. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5137893-A | Anxilytic agents; antidepressants; antiemetics | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |