Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 3/20 | 0.66 |
| ▸ | JAK1 | P23458 | 3/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929613 | 0.90 | JAK2 (0.78) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL7330825 | 0.88 | JAK2 (0.66) | HDAC8JAK2JAK1TYK2MEN1 | |
| SCHEMBL20601659 | 0.88 | HDAC8 (0.67) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL5336489 | 0.86 | SMN1; SMN2 (0.65) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL3729379 | 0.85 | HDAC8 (0.56) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL6005591 | 0.84 | JAK2 (0.69) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL5341743 | 0.84 | HDAC8 (0.62) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL2009824 | 0.84 | SMN1; SMN2 (0.70) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL11575341 | 0.83 | ALDH1A1 (0.69) | HDAC8JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL10612716 | 0.82 | TMPRSS4 (0.73) | HDAC8JAK2JAK1TYK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064354-C | Antimicrobial 5- (N-heterosubstituted amino) quinolones and pharmaceutical compositions | AMERICAN CYANAMID CO (US) | 2001-04-11 | — | — | CN | disclosed |
| US-5869483-A | KIDNEY DISEASES | AMERICAN CYANAMID COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5854236-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843952-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5834461-A | TREATING CONGESTIVE HEART FAILURE | AMERICAN CYANAMID COMPANY (US) | 1998-11-10 | — | — | US | disclosed |
| US-5786353-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-07-28 | — | — | US | disclosed |
| US-5760031-A | KIDNEY DISEASES | AMERICAN CYANAMID COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5747487-A | N-(4-((4,5-DIHYDRO-6H-THIAZOL(5,4-D)(1)BENZAZEPIN-6-YL) -CARBONYL)PHENYL)BENZAMIDES; DISEASES CHARATERIZED BY EXCESS RENAL ABSORPTION OF WATER, E.G. CONGESTIVE HEART DISEASE, HYERTENSION; OXYTOCIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| US-5739128-A | ADMINISTERING FOR TREATMENT OF DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| US-5736538-A | TREATS IN MAMMAL THE DISEASE CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER, IS CONGESTIVE HEART FAILURE, NEPHROTIC SYNDROME, HYPONATREMIA, CORONARY AND RENAL VASOSPASM, CARDIAC ISCHEMIA, LIVER CIRRHOSIS AND BRAIN EDEMA | AMERICAN CYANAMID COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| US-5693635-A | TREATMENT OF DISEASES CHARACTERIZED BY EXCESS RENAL ABSORPTION OF WATER; CONGESTIVE HEART FAILURE, NEPHROTIC SYNDROME | AMERICAN CYANAMID COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5686445-A | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| US-5512563-A | TREATING DISEASES CAUSED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |