Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | JAK1 | P23458 | 1/20 | 0.69 |
| ▸ | TYK2 | P29597 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.66 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.63 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | TMPRSS4 | Q9NRS4 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929613 | 0.93 | JAK2 (0.78) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL14228391 | 0.87 | JAK2 (0.69) | JAK2JAK1TYK2P2RX1MEN1 | |
| SCHEMBL30692659 | 0.87 | P2RX1 (0.87) | LMNAP2RX1MEN1KMT2ATMPRSS4 | |
| SCHEMBL24438716 | 0.87 | P2RX1 (0.87) | LMNAP2RX1MEN1KMT2ATMPRSS4 | |
| SCHEMBL11575341 | 0.85 | ALDH1A1 (0.69) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL10612716 | 0.85 | TMPRSS4 (0.73) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL20601659 | 0.84 | HDAC8 (0.67) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL7329845 | 0.84 | HDAC8 (0.67) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL5336489 | 0.83 | SMN1; SMN2 (0.65) | JAK2JAK1TYK2ALDH1A1LMNA | |
| SCHEMBL11575433 | 0.81 | ALDH1A1 (0.63) | JAK2JAK1TYK2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054530-A2 | CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES | ELCELYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |