Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 6/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | HPD | P32754 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324875 | 0.84 | DPP4 (0.49) | ALDH1A1MEN1KMT2ARAB9ARORC | |
| SCHEMBL7330260 | 0.84 | RAB9A (0.57) | ALDH1A1MEN1KMT2ARAB9ADPP4 | |
| SCHEMBL11128101 | 0.83 | RAB9A (0.56) | ALDH1A1MEN1KMT2ARAB9ADPP4 | |
| SCHEMBL11128097 | 0.82 | RAB9A (0.55) | ALDH1A1MEN1KMT2ARAB9ADPP4 | |
| Oxalic Acid SCHEMBL7325487 | 0.70 | KMT2A (0.43) | ALDH1A1MEN1KMT2ARAB9ADPP4 | |
| SCHEMBL7330601 | 0.69 | FFAR4 (0.41) | MMP1ADAM17FFAR4HPD | |
| SCHEMBL7331567 | 0.68 | FFAR4 (0.37) | ALDH1A1MMP1ADAM17GPR183FFAR4 | |
| SCHEMBL13034127 | 0.67 | GAA (0.47) | ALDH1A1HPD | |
| SCHEMBL3088869 | 0.67 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AOPRL1 | |
| SCHEMBL10555660 | 0.65 | CYP2D6 (0.39) | ALDH1A1RORCDPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102034-B1 | SPIRO(2H-1,4-BENZODIOXEPIN-3(5H)4'-PIPERIDINE AND 3'-PYRROLIDINO) COMPOUNDS, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-04-20 | — | — | EP | disclosed |
| US-4521537-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0102034-A1 | Spiro(2H-1,4-benzodioxepin-3(5H)4'-piperidine and 3'-pyrrolidino) compounds, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-03-07 | — | — | EP | disclosed |