Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.64 |
| ▸ | DRD3 | P35462 | 11/20 | 0.64 |
| ▸ | DRD4 | P21917 | 9/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 5/20 | 0.64 |
| ▸ | HTR7 | P34969 | 5/20 | 0.64 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329469 | 0.96 | DRD2 (0.64) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL9137868 | 0.85 | DRD2 (0.59) | DRD2DRD3DRD4HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL7327180 | 0.82 | SIGMAR1 (0.57) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL7329553 | 0.82 | DRD2 (0.58) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL26108725 | 0.79 | KCNH2 (0.85) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL26107525 | 0.79 | KCNH2 (0.85) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4519313 | 0.79 | KCNH2 (0.85) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10332824 | 0.78 | DRD2 (0.63) | DRD2DRD3DRD4HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL7321381 | 0.78 | SIGMAR1 (0.56) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL27237006 | 0.78 | HTR1A (1.00) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592453-B1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AG (DE) | 1998-12-16 | — | — | EP | disclosed |
| US-5424312-A | Treating central nervous system disorders, high blood pressure | BASF AKTIENGESELLSCHAFT (DE) | 1995-06-13 | — | — | US | disclosed |
| EP-0592453-A1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1994-04-20 | — | — | EP | disclosed |
| WO-1992022541-A1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | WO | disclosed |