Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338995 | 0.87 | HIF1A (0.58) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| SCHEMBL14624903 | 0.81 | BCHE (0.55) | ALDH1A1LMNAKDM4EMAPTMEN1 | |
| SCHEMBL16644326 | 0.80 | LMNA (0.47) | ALDH1A1LMNAKDM4EMAPTTSHR | |
| SCHEMBL3652526 | 0.77 | HIF1A (0.58) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| SCHEMBL29511863 | 0.77 | HIF1A (0.58) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| SCHEMBL23337952 | 0.77 | HIF1A (0.71) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Hydrochloric Acid SCHEMBL3656870 | 0.76 | ADRB2 (0.59) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| SCHEMBL14787923 | 0.76 | LMNA (0.44) | ALDH1A1LMNAKDM4EMAPTMEN1 | |
| SCHEMBL23318966 | 0.75 | HIF1A (0.72) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| SCHEMBL20142394 | 0.75 | HIF1A (0.67) | HIF1AALDH1A1LMNACYP3A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767792-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0767792-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000730-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |