Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | BLM | P54132 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | THPO | P40225 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330837 | 0.87 | HIF1A (0.56) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL11577699 | 0.81 | ALDH1A1 (0.56) | HIF1AALDH1A1ADRB2TDP1KDM4E | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL7553688 | 0.79 | TDP1 (0.60) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL21480795 | 0.79 | HIF1A (0.50) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Hydrochloric Acid SCHEMBL23040681 | 0.78 | HIF1A (0.51) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Hydrochloric Acid SCHEMBL23040679 | 0.78 | HIF1A (0.51) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL23318966 | 0.77 | HIF1A (0.72) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL23337952 | 0.75 | HIF1A (0.71) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL20142145 | 0.75 | HIF1A (0.71) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| SCHEMBL29511863 | 0.75 | HIF1A (0.58) | HIF1AALDH1A1CYP3A4LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767792-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0767792-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000730-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |