SCHEMBL7330959

SCHEMBL7330959

O=C(O)c1ccccc1Nc1ccnn1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 2/20 0.46
CDC7 O00311 1/20 0.46
PBRM1 Q86U86 1/20 0.46
CLCN2 P51788 4/20 0.45
CHRM4 P08173 1/20 0.45
CHRM3 P20309 1/20 0.45
FTO Q9C0B1 2/20 0.45
TTR P02766 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
USP2 O75604 1/20 0.45
MT-CO2 P00403 1/20 0.45
LMNA P02545 1/20 0.45
PLA2G1B P04054 1/20 0.45
CYP1A2 P05177 1/20 0.45
PGR P06401 1/20 0.45
CYP3A4 P08684 1/20 0.45
HTR1A P08908 1/20 0.45
ADRA2A P08913 1/20 0.45
ADORA3 P0DMS8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5008627 0.85 MAPK8 (0.50) MAPK8PBRM1CLCN2FTOTTR
SCHEMBL5473412 0.77 SMO (0.49) MAPK8CLCN2TTRMEN1KMT2A
SCHEMBL6343810 0.74 GFER (0.52) FTOTTRMEN1KMT2AUSP2
SCHEMBL7420128 0.74 FABP4 (0.45) MAPK8CLCN2FTOTTRMEN1
SCHEMBL28734876 0.72 ALDH1A1 (0.46) MEN1KMT2ALMNACYP1A2
SCHEMBL6345006 0.72 OXTR (0.45) MAPK8CDC7MEN1KMT2AMAPT
SCHEMBL6344420 0.72 GFER (0.49) FTOUSP2LMNAMAPTHPGD
SCHEMBL17869333 0.71 GRN (0.51) MEN1KMT2AHPGDRECQL
SCHEMBL7332935 0.71 KMT2A (0.53) MAPK8CDC7MEN1KMT2AFABP4
SCHEMBL355549 0.70 FABP4 (0.80) PBRM1CLCN2TTRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0813533-A4 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP INC (US) 2000-01-19 EP disclosed
US-5942520-A Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines CELL PATHWAYS, INC. (US) 1999-08-24 US disclosed
EP-0813533-A1 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-12-29 EP disclosed
WO-1996028446-A1 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-09-19 WO disclosed
US-5488055-A ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS SANOFI WINTHROP INC. (US) 1996-01-30 US disclosed