Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333146 | 0.90 | KMT2A (0.40) | RENCTSSFFAR2KMT2A | |
| SCHEMBL7331049 | 0.88 | REN (0.35) | RENRORCALOX5APFEN1GFER | |
| SCHEMBL7334862 | 0.86 | RORC (0.33) | RORCALOX5APFEN1GFERCTSS | |
| SCHEMBL7332856 | 0.86 | REN (0.38) | RENCTSSFFAR2KMT2A | |
| SCHEMBL7336480 | 0.85 | REN (0.38) | RENKMT2A | |
| SCHEMBL7339920 | 0.85 | REN (0.36) | RENRORCALOX5APFEN1GFER | |
| SCHEMBL7332394 | 0.84 | RORC (0.32) | RENRORCALOX5APFEN1GFER | |
| SCHEMBL7331624 | 0.83 | FFAR2 (0.32) | RENCTSSFFAR2 | |
| SCHEMBL7330654 | 0.83 | REN (0.38) | RENCTSSFFAR2KMT2A | |
| SCHEMBL7378656 | 0.80 | REN (0.38) | RENCTSSFFAR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |