Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | IAPP | P10997 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324988 | 0.89 | TDP1 (0.38) | TDP1SMN1; SMN2TSHRBRD4IAPP | |
| SCHEMBL19211596 | 0.81 | SMN1; SMN2 (0.44) | TDP1SMN1; SMN2TSHRALDH1A1HSD17B10 | |
| SCHEMBL3956931 | 0.71 | MAPT (0.42) | TDP1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL2964830 | 0.69 | SMN1; SMN2 (0.43) | TDP1SMN1; SMN2TSHRALDH1A1HSD17B10 | |
| SCHEMBL14899668 | 0.69 | TSHR (0.48) | TSHRALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL31487937 | 0.68 | ALDH1A1 (0.39) | SMN1; SMN2TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL7325840 | 0.68 | SMN1; SMN2 (0.42) | TDP1SMN1; SMN2TSHRALDH1A1HSD17B10 | |
| SCHEMBL14188912 | 0.67 | KMT2A (0.44) | SMN1; SMN2TSHRBRD4ALDH1A1HSD17B10 | |
| SCHEMBL9728892 | 0.67 | CYSLTR2 (0.40) | TDP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13516183 | 0.66 | KDM4E (0.46) | TDP1SMN1; SMN2TSHRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4924010-A | GASTROINTESTINAL DISORDERS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-05-08 | — | — | US | disclosed |
| US-4859683-A | Certain benzoxepins and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| US-4857517-A | Quinuclidyl benzoxepins as 5-HT3 antagonists | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |