Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 4/20 | 0.70 |
| ▸ | REN | P00797 | 4/20 | 0.61 |
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 3/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | ECE1 | P42892 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.51 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.51 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.51 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.51 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.51 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.51 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.51 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095633 | 0.98 | CTSD (0.70) | CTSDRENCTSKCTSBELANE | |
| SCHEMBL6132144 | 0.93 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL6449641 | 0.93 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| Acetic Acid SCHEMBL7270658 | 0.91 | CTSD (0.73) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL9232828 | 0.91 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL9740721 | 0.91 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL6446780 | 0.91 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL6446151 | 0.91 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL6445103 | 0.91 | CTSD (0.76) | CTSDRENCTSKCTSBTRPM8 | |
| SCHEMBL6446525 | 0.91 | CTSD (0.60) | CTSDRENCTSKCTSBTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |