Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.60 |
| ▸ | CTSK | P43235 | 5/20 | 0.59 |
| ▸ | REN | P00797 | 2/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095633 | 0.93 | CTSD (0.70) | CTSDCTSKRENTRPM8CTSB | |
| SCHEMBL7332296 | 0.91 | CTSD (0.70) | CTSDCTSKRENTRPM8CTSB | |
| SCHEMBL4949767 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL2736202 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL7337287 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL2736218 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL9421829 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL5916913 | 0.88 | TRPM8 (0.64) | CTSDCTSKTRPM8TACR1CTRB1 | |
| SCHEMBL6446780 | 0.88 | CTSD (0.76) | CTSDCTSKRENTRPM8TACR1 | |
| SCHEMBL6446151 | 0.88 | CTSD (0.76) | CTSDCTSKRENTRPM8TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |