Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 7/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331301 | 0.91 | REN (0.45) | RENCTSSOPRL1 | |
| SCHEMBL7331049 | 0.90 | REN (0.35) | KMT2ARENCTSS | |
| SCHEMBL7329328 | 0.90 | REN (0.46) | KMT2ARENCTSSPSMB5 | |
| SCHEMBL7339618 | 0.88 | REN (0.45) | RENCTSSOPRL1 | |
| SCHEMBL7339560 | 0.88 | REN (0.36) | RENCTSS | |
| SCHEMBL7333146 | 0.86 | KMT2A (0.40) | KMT2ARENCTSSSLC6A4OPRL1 | |
| SCHEMBL7337649 | 0.85 | KMT2A (0.43) | KMT2ARENCTSSSLC6A4 | |
| SCHEMBL7333921 | 0.84 | REN (0.41) | KMT2ARENSLC6A4PSMB5 | |
| SCHEMBL7376719 | 0.84 | REN (0.46) | RENCTSSOPRL1 | |
| SCHEMBL7338907 | 0.83 | KMT2A (0.41) | KMT2ARENCTSSSLC6A4OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |