Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 2/20 | 0.30 |
| ▸ | PLAU | P00749 | 2/20 | 0.30 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.30 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.30 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339105 | 0.91 | HSD17B10 (0.37) | KMT2ACTSSTSHRGAACYP2C19 | |
| SCHEMBL7339877 | 0.90 | LMNA (0.38) | KMT2ACTSSGAACYP2C19ALDH1A1 | |
| SCHEMBL7334862 | 0.89 | RORC (0.33) | KMT2ACTSS | |
| SCHEMBL7338647 | 0.88 | CTSS (0.33) | KMT2ACTSS | |
| SCHEMBL7338555 | 0.88 | REN (0.36) | KMT2ACTSSTSHRGAACYP2C19 | |
| SCHEMBL7332502 | 0.85 | KMT2A (0.41) | KMT2ACTSSSLC6A4REN | |
| SCHEMBL7333146 | 0.85 | KMT2A (0.40) | KMT2ACTSSSLC6A4LMNAREN | |
| SCHEMBL7332211 | 0.83 | REN (0.39) | KMT2ASLC6A4TSHRCYP2C19PLG | |
| SCHEMBL7331323 | 0.82 | KMT2A (0.41) | KMT2ACTSSSLC6A4SLC6A2LTA4H | |
| SCHEMBL7338907 | 0.82 | KMT2A (0.41) | KMT2ACTSSSLC6A4SLC6A2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |