Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 6/20 | 0.35 |
| ▸ | F2 | P00734 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330956 | 0.92 | REN (0.46) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7339920 | 0.90 | REN (0.36) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7337422 | 0.90 | REN (0.40) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7330659 | 0.89 | REN (0.46) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7333699 | 0.88 | REN (0.38) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7332487 | 0.84 | REN (0.42) | KMT2ARENF10F2PLG | |
| SCHEMBL7331323 | 0.83 | KMT2A (0.41) | KMT2ARENCTSSOPRL1F10 | |
| SCHEMBL7332502 | 0.83 | KMT2A (0.41) | KMT2ARENCTSSOPRL1SLC6A4 | |
| SCHEMBL7333146 | 0.83 | KMT2A (0.40) | KMT2ARENCTSSOPRL1SLC6A4 | |
| SCHEMBL7337649 | 0.82 | KMT2A (0.43) | KMT2ARENCTSSF10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |