Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334542 | 0.88 | CYP2D6 (0.56) | CYP2C19TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL7330813 | 0.87 | HSD17B10 (0.50) | HSD17B10GAACYP2C19TSHRCHRM1 | |
| SCHEMBL7338169 | 0.87 | HSD17B10 (0.50) | HSD17B10GAACYP2C19TSHRCHRM1 | |
| Hydrochloric Acid SCHEMBL7338311 | 0.86 | KMT2A (0.55) | HSD17B10GAACYP2C19TSHRALDH1A1 | |
| SCHEMBL7384720 | 0.81 | GAA (0.45) | HSD17B10GAACYP2C19CHRM1ALDH1A1 | |
| SCHEMBL7353235 | 0.80 | REN (0.47) | HSD17B10CTSSREN | |
| SCHEMBL7300947 | 0.78 | KMT2A (0.43) | GAACYP2C19MEN1KMT2AREN | |
| SCHEMBL21962937 | 0.77 | KMT2A (0.51) | HSD17B10CYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL7329490 | 0.77 | REN (0.54) | REN | |
| SCHEMBL6578384 | 0.76 | HPGD (0.44) | HSD17B10TSHRALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523289-A | RENIN INHIBITOR | ABBOTT LABORATORIES (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5344990-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-09-06 | — | — | US | disclosed |
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| US-5275950-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-01-04 | — | — | US | disclosed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1993007886-A1 | PHARMACEUTICAL COMPOSITION CONTAINING CERTAIN PEPTIDOMIMETIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-04-29 | — | — | WO | disclosed |
| WO-1993002667-A1 | PHARMACEUTICAL COMPOSITION | ABBOTT LABORATORIES (US) | 1993-02-18 | — | — | WO | disclosed |
| US-5182266-A | Method for treating renal disease | ABBOTT LABORATORIES (US) | 1993-01-26 | — | — | US | disclosed |
| US-5178877-A | Cardiovascular disorders | ABBOTT LABORATORIES (US) | 1993-01-12 | — | — | US | disclosed |
| US-5122514-A | Administering renin inhibitor | ABBOTT LABORATORIES (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |
| WO-1991016031-A1 | PSORIASIS TREATMENT | ABBOTT LABORATORIES (US) | 1991-10-31 | — | — | WO | disclosed |