Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 3/20 | 0.45 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338169 | 1.00 | HSD17B10 (0.50) | HSD17B10CYP1A2CHRM1IDO1CPA3 | |
| SCHEMBL7333389 | 0.87 | CYP1A2 (0.54) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL7332863 | 0.87 | HSD17B10 (0.46) | HSD17B10CHRM1IDO1CTSSPOLB | |
| SCHEMBL7301756 | 0.84 | LMNA (0.56) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL8909332 | 0.84 | LMNA (0.56) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL7353235 | 0.81 | REN (0.47) | HSD17B10CTSS | |
| SCHEMBL7330013 | 0.81 | CYP1A2 (0.44) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL7336528 | 0.81 | TSHR (0.50) | TSHRALDH1A1GAACYP2C19 | |
| SCHEMBL7148417 | 0.80 | POLB (0.55) | POLBTSHRALDH1A1KMT2A | |
| SCHEMBL9437516 | 0.80 | REN (0.38) | HSD17B10CHRM1IDO1CTSSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | claimed |
| EP-0655063-B1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS HAVING A PIPERAZINYL-TERMINATED GROUP OR A PIPERAZINYL-ALKYLAMINO-TERMINATED GROUP FOR TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5523289-A | RENIN INHIBITOR | ABBOTT LABORATORIES (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5344990-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-09-06 | — | — | US | disclosed |
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5298505-A | Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension | G. D. SEARLE & CO. (US) | 1994-03-29 | — | — | US | disclosed |
| WO-1994004536-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS HAVING A PIPERAZINYL-TERMINATED GROUP OR A PIPERAZINYL-ALKYLAMINO-TERMINATED GROUP FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1994-03-03 | — | — | WO | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| US-5275950-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-01-04 | — | — | US | disclosed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1993007886-A1 | PHARMACEUTICAL COMPOSITION CONTAINING CERTAIN PEPTIDOMIMETIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-04-29 | — | — | WO | disclosed |
| WO-1993002667-A1 | PHARMACEUTICAL COMPOSITION | ABBOTT LABORATORIES (US) | 1993-02-18 | — | — | WO | disclosed |
| US-5182266-A | Method for treating renal disease | ABBOTT LABORATORIES (US) | 1993-01-26 | — | — | US | disclosed |
| US-5178877-A | Cardiovascular disorders | ABBOTT LABORATORIES (US) | 1993-01-12 | — | — | US | disclosed |
| US-5122514-A | Administering renin inhibitor | ABBOTT LABORATORIES (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |
| WO-1991016031-A1 | PSORIASIS TREATMENT | ABBOTT LABORATORIES (US) | 1991-10-31 | — | — | WO | disclosed |