Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | MME | P08473 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329490 | 0.88 | REN (0.54) | RENMMEERAP2ERAP1LNPEP | |
| SCHEMBL7328611 | 0.85 | REN (0.53) | RENMMEERAP2ERAP1LNPEP | |
| SCHEMBL7338166 | 0.83 | LTA4H (0.49) | RENLTA4HMMEANPEP | |
| SCHEMBL7330813 | 0.81 | HSD17B10 (0.50) | CTSSHSD17B10 | |
| SCHEMBL7338169 | 0.81 | HSD17B10 (0.50) | CTSSHSD17B10 | |
| SCHEMBL7333546 | 0.80 | LTA4H (0.46) | RENLTA4HMMEANPEP | |
| SCHEMBL7332863 | 0.80 | HSD17B10 (0.46) | RENCTSSHSD17B10 | |
| SCHEMBL7336427 | 0.77 | FCER2 (0.49) | RENMMEERAP2ERAP1LNPEP | |
| SCHEMBL7330912 | 0.77 | REN (0.54) | RENMMECTSSERAP2ERAP1 | |
| SCHEMBL7336719 | 0.75 | FCER2 (0.47) | RENMMEERAP2ERAP1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |