SCHEMBL7333258

CC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cscn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1

nearest known ligand 0.83

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	19/20	0.83

▸	P2RX1	P51575	1/20	0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7333284	1.00	REN (0.83)	RENP2RX1
SCHEMBL9286697	0.89	REN (0.68)	REN
SCHEMBL9283652	0.89	REN (0.68)	REN
Remikiren SCHEMBL156393	0.88	REN (0.76)	REN
Remikiren SCHEMBL22263508	0.88	REN (0.76)	REN
Remikiren SCHEMBL9556708	0.88	REN (0.76)	REN
Remikiren SCHEMBL8352292	0.88	REN (0.76)	REN
Remikiren SCHEMBL9556439	0.88	REN (0.76)	REN
Remikiren SCHEMBL7303589	0.88	REN (0.76)	REN
Remikiren SCHEMBL8352030	0.88	REN (0.76)	REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5256645-A	Renin inhibitors; hypotensive agents	HOFFMANN-LA ROCHE INC. (US)	1993-10-26	—	—	US	claimed
US-5389616-A	Renin inhibitor, hypotensive agent	HOFFMAN-LAROCHE INC. (US)	1995-02-14	—	—	US	disclosed
US-5256645-A	Renin inhibitors; hypotensive agents	HOFFMANN-LA ROCHE INC. (US)	1993-10-26	—	—	US	disclosed
US-5134123-A	Renin enzyme inhibitors for cardiovascular disorders and high blood pressure	HOFFMAN-LA ROCHE INC. (US)	1992-07-28	—	—	US	disclosed
EP-0332008-A2	Peptide-like aminoacid derivatives	F. HOFFMANN-LA ROCHE AG (CH)	1989-09-13	—	—	EP	disclosed