Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333258 | 1.00 | REN (0.83) | RENP2RX1 | |
| SCHEMBL9286697 | 0.89 | REN (0.68) | REN | |
| SCHEMBL9283652 | 0.89 | REN (0.68) | REN | |
| Remikiren SCHEMBL156393 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL22263508 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL9556708 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL8352292 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL9556439 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL7303589 | 0.88 | REN (0.76) | REN | |
| Remikiren SCHEMBL8352030 | 0.88 | REN (0.76) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0332008-A2 | Peptide-like aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-09-13 | — | — | EP | disclosed |