Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724551 | 0.89 | GPR84 (0.69) | CSNK2A1GPR84HTR2BHTR2AHTR1A | |
| SCHEMBL8868480 | 0.86 | GPR84 (0.58) | CSNK2A1GPR84HTR2BHTR2AHTR1A | |
| SCHEMBL6574193 | 0.83 | CSNK2A1 (0.61) | CSNK2A1SLC6A4 | |
| SCHEMBL7335081 | 0.82 | CSNK2A1 (0.60) | CSNK2A1GPR84HTR2AMAPTTRPM8 | |
| SCHEMBL7327065 | 0.82 | CSNK2A1 (0.60) | CSNK2A1GPR84HTR2AHTR1ATSHR | |
| SCHEMBL2727889 | 0.80 | HTR2A (0.62) | CSNK2A1GPR84HTR2BHTR2AHTR1A | |
| SCHEMBL7331404 | 0.80 | HTR1A (0.79) | HTR2BHTR2AHTR1AHTR2CCYP2D6 | |
| SCHEMBL4945471 | 0.78 | CSNK2A1 (0.56) | CSNK2A1GPR84HTR1DHTR1BSLC6A4 | |
| SCHEMBL7332860 | 0.77 | HTR1D (0.80) | HTR2BHTR2AHTR1AHTR2CCYP2D6 | |
| SCHEMBL18311441 | 0.77 | HTR1B (0.56) | CSNK2A1GPR84HTR2BHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |