Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573751 | 0.82 | RXRA (0.57) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL28669599 | 0.82 | ALDH1A1 (0.54) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL7326556 | 0.82 | ALDH1A1 (0.56) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL7331010 | 0.79 | RXRA (0.60) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL7335957 | 0.78 | LMNA (0.67) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL13256427 | 0.73 | ALDH1A1 (0.61) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL4573756 | 0.73 | HTT (0.51) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL2357753 | 0.73 | ALDH1A1 (0.63) | ALDH1A1RXRARXRBRXRGMEN1 | |
| SCHEMBL11935623 | 0.73 | HTT (0.51) | ALDH1A1RXRARXRBRXRGHDAC6 | |
| SCHEMBL8166642 | 0.73 | HTT (0.58) | ALDH1A1RXRARXRBRXRGHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |