Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865562 | 0.87 | SIGMAR1 (0.50) | GRIN2BCYP2D6CYP1A2LMNASIGMAR1 | |
| SCHEMBL8677037 | 0.84 | DRD4 (0.58) | KDM4EDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL7423933 | 0.83 | DRD4 (0.56) | KDM4EDRD2DRD4DRD3 | |
| SCHEMBL8964119 | 0.81 | LMNA (0.53) | KMT2AATMHTTLMNACYP2C19 | |
| Hydrochloric Acid SCHEMBL7420060 | 0.81 | GRIN2B (0.52) | GRIN2BKDM4EALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL6901339 | 0.81 | DRD4 (0.60) | CYP2D6KDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL27465127 | 0.79 | DRD4 (0.62) | KDM4EALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12204393 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1LMNADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL7421744 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL8675895 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1HSD17B10KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240245670-A1 | DOSING REGIMEN AND PHARMACEUTICAL COMBINATION COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | NOVARTIS AG (CH) | 2024-07-25 | — | — | US | disclosed |
| US-6166205-A | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands | NEUROGEN CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000012500-A2 | 2-ARYL-4-(1-[4-HETEROARYL]PIPERAZIN-1-YL) METHYLIMIDAZOLES: DOPAMINE D4 RECEPTOR SUBTYPE LIGANDS | NEUROGEN CORPORATION (US) | 2000-03-09 | — | — | WO | disclosed |
| US-5633376-A | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands | NEUROGEN CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5428164-A | Useful for treating and diagnosis of schizophrenia and depression as well as parkinson's disease | NEUROGEN CORPORATION (US) | 1995-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240245670-A1 | DOSING REGIMEN AND PHARMACEUTICAL COMBINATION COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | IKZF1, IKZF2, IKZF3 | GRIN2B 3733/4885CYP2D6 1576/4885CYP1A2 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.