Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 17/20 | 0.61 |
| ▸ | MMP1 | P03956 | 7/20 | 0.61 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345089 | 0.83 | MMP3 (0.55) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL7339581 | 0.82 | MMP3 (0.52) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL7341498 | 0.80 | CA1 (0.44) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL7332421 | 0.77 | CA1 (0.41) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6968594 | 0.77 | MMP3 (0.71) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7335781 | 0.76 | MMP3 (0.53) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6954663 | 0.76 | MMP3 (1.00) | MMP3MMP1MMP2 | |
| SCHEMBL6954669 | 0.76 | MMP3 (1.00) | MMP3MMP1MMP2 | |
| SCHEMBL6954611 | 0.75 | MMP3 (0.81) | MMP3MMP1MMP2 | |
| SCHEMBL6952846 | 0.74 | MMP3 (0.80) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847148-A | Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-08 | — | — | US | disclosed |