Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 10/20 | 0.60 |
| ▸ | ACE | P12821 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PREP | P48147 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359927 | 0.92 | ACE (0.67) | ACELMNAPREPSMN1; SMN2 | |
| SCHEMBL7329937 | 0.92 | ACE (0.67) | ACELMNAPREPSMN1; SMN2 | |
| SCHEMBL23502313 | 0.89 | FKBP1A (0.62) | FKBP1AACELMNAPREPSMN1; SMN2 | |
| SCHEMBL21696841 | 0.87 | FKBP1A (0.60) | FKBP1AACELMNAPREPSMN1; SMN2 | |
| SCHEMBL10968745 | 0.86 | ACE (0.58) | FKBP1AACELMNAPREPSMN1; SMN2 | |
| SCHEMBL11940447 | 0.86 | FKBP1A (0.64) | FKBP1AACEPREP | |
| SCHEMBL6788139 | 0.86 | FKBP1A (0.64) | FKBP1AACEPREP | |
| SCHEMBL6788131 | 0.86 | FKBP1A (0.64) | FKBP1AACEPREP | |
| SCHEMBL7331311 | 0.86 | ACE (0.78) | FKBP1AACELMNASMN1; SMN2 | |
| SCHEMBL7331306 | 0.86 | ACE (0.78) | FKBP1AACELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |