Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328473 | 1.00 | HTR2A (0.53) | HTR2AELANECTSLCTSBCTSS | |
| SCHEMBL7278888 | 0.90 | CTSL (0.55) | HTR2ACTSLCTSBCTSSCTSK | |
| SCHEMBL7278892 | 0.90 | CTSL (0.55) | HTR2ACTSLCTSBCTSSCTSK | |
| SCHEMBL11771667 | 0.90 | CTSL (0.55) | HTR2ACTSLCTSBCTSSCTSK | |
| SCHEMBL29838911 | 0.90 | HTR2A (0.55) | HTR2AELANECTSLCTSBCTSS | |
| SCHEMBL8432555 | 0.90 | CTSB (0.53) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL1801469 | 0.90 | HTR2A (0.56) | HTR2ACTSLCTSBCTSSCTSK | |
| SCHEMBL10794620 | 0.90 | HTR2A (0.56) | HTR2ACTSLCTSBCTSSCTSK | |
| SCHEMBL8432553 | 0.90 | CTSB (0.53) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL6446459 | 0.89 | HTR2A (0.51) | HTR2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3038553-A | — | — | None | — | — | JP | disclosed |
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |
| JP-H0338553-A | ASYMMETRICALLY REACTIVE INORGANIC OXIDE POWDER CARRYING AMINO ACID | OSAKA ORGANIC CHEM IND LTD | 1991-02-19 | — | — | JP | disclosed |