Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333796 | 0.91 | ADRA1A (0.47) | MMP8MMP3HTTNPC1RAB9A | |
| SCHEMBL6851321 | 0.84 | HPGD (0.48) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL7011484 | 0.82 | NPC1 (0.50) | MMP8MMP3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9617115 | 0.82 | EPHX2 (0.55) | MMP8MMP3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7326401 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL7328287 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL7326394 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| Fumaric Acid SCHEMBL7334141 | 0.80 | HPGD (0.43) | NPC1RAB9ASMN1; SMN2LIMK2MEN1 | |
| Hydrochloric Acid SCHEMBL7324768 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL7331894 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |