Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851321 | 0.94 | HPGD (0.48) | HPGDMAPTMEN1GAAKMT2A | |
| Fumaric Acid SCHEMBL7334153 | 0.91 | ADRA1A (0.47) | HPGDMAPTMEN1GAAKMT2A | |
| Fumaric Acid SCHEMBL7334775 | 0.86 | POLB (0.38) | HPGDMAPTMEN1KMT2AADRA1A | |
| Fumaric Acid SCHEMBL7332340 | 0.84 | LMNA (0.42) | HPGDMEN1KMT2AADRA1AHSD17B10 | |
| Fumaric Acid SCHEMBL7330519 | 0.84 | SMN1; SMN2 (0.49) | HPGDMEN1GAAKMT2AADRA1A | |
| Fumaric Acid SCHEMBL7324439 | 0.83 | CYP2C9 (0.43) | MAPTMEN1GAAKMT2ANPC1 | |
| Fumaric Acid SCHEMBL7325579 | 0.83 | GAA (0.55) | HPGDMAPTMEN1GAAKMT2A | |
| Fumaric Acid SCHEMBL7323992 | 0.83 | KDM4E (0.51) | HPGDMAPTGAAKMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL7331885 | 0.82 | SMN1; SMN2 (0.48) | HPGDMEN1GAAKMT2ALMNA | |
| SCHEMBL9048814 | 0.82 | GSK3A (0.47) | HPGDKMT2AKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |