Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181845 | 0.80 | MAOB (0.38) | PDK1PDK2PDK3PDK4CTSL | |
| SCHEMBL29177432 | 0.75 | HTR3A (0.43) | PTGESHTR3A | |
| SCHEMBL29791412 | 0.71 | HTR3A (0.40) | HTR3A | |
| SCHEMBL25128557 | 0.71 | ANO1 (0.38) | PTGESPDK1PDK2PDK3PDK4 | |
| SCHEMBL18181782 | 0.70 | HTR3A (0.38) | PTGESHTR3A | |
| SCHEMBL7335337 | 0.70 | HTR3A (0.43) | NOTUMHTR3A | |
| SCHEMBL9868892 | 0.70 | HTR3A (0.43) | NOTUMHTR3A | |
| SCHEMBL8545657 | 0.70 | PARP1 (0.49) | PTGESTP53MAPT | |
| SCHEMBL6583702 | 0.70 | PARP1 (0.47) | NOTUM | |
| SCHEMBL6375223 | 0.69 | NPC1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684947-A1 | AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994019344-A1 | AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1994-09-01 | — | — | WO | disclosed |