Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17799994 | 0.84 | APP (0.58) | HPGDMAPK1GSK3BCYP2D6APP | |
| SCHEMBL7330878 | 0.83 | KCNA5 (0.42) | KCNA5JAK2IGF1RPIM1SRC | |
| SCHEMBL3641178 | 0.77 | APP (0.68) | KCNA5JAK2IGF1RPIM1SRC | |
| SCHEMBL7337359 | 0.75 | KDM4E (0.51) | MAPK1KCNA5JAK2IGF1RPIM1 | |
| SCHEMBL25242224 | 0.72 | CSNK2A1 (0.46) | CSNK2A2CSNK2A1APPPDE5AAURKA | |
| SCHEMBL7417929 | 0.72 | FAAH (0.47) | KCNA5GSK3BAPPPDE5AKDM4E | |
| SCHEMBL654721 | 0.71 | L3MBTL1 (0.49) | HPGDMAPK1CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL17799848 | 0.71 | APP (0.63) | APPPDE5A | |
| SCHEMBL7711077 | 0.70 | SMN1; SMN2 (0.53) | CYP2D6 | |
| SCHEMBL6204828 | 0.70 | CYP2D6 (0.40) | HPGDMAPK1CDK5CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |