Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333000 | 0.92 | RAB9A (0.39) | LMNAMAOACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL8896516 | 0.84 | RAB9A (0.44) | LMNAALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL7340687 | 0.83 | ALDH1A1 (0.41) | LMNAALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL7329464 | 0.81 | SMN1; SMN2 (0.53) | LMNAALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7328886 | 0.80 | SMN1; SMN2 (0.47) | CYP3A4ALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL3418853 | 0.78 | MAOA (0.50) | LMNAMAOACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL20251278 | 0.78 | NR1H2 (0.39) | CYP3A4ALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL15357999 | 0.77 | KDM4E (0.38) | LMNACYP1A2CYP3A4ALDH1A1MAPT | |
| SCHEMBL16529730 | 0.77 | SYK (0.41) | LMNAALDH1A1MAPTSYKCA12 | |
| Hydrochloric Acid SCHEMBL2876219 | 0.77 | MAOA (0.49) | LMNAMAOACYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |