Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 18/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731315 | 0.86 | ROCK2 (0.47) | ROCK2ROCK1CREBBP | |
| SCHEMBL15995786 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1 | |
| SCHEMBL730974 | 0.77 | S1PR1 (0.42) | CREBBPS1PR1 | |
| SCHEMBL1501791 | 0.76 | S1PR1 (0.51) | CREBBPS1PR1 | |
| SCHEMBL731379 | 0.76 | PDK2 (0.45) | CREBBPS1PR1 | |
| SCHEMBL730899 | 0.74 | AAK1 (0.44) | — | |
| SCHEMBL25048663 | 0.73 | TDO2 (0.49) | CREBBPS1PR1 | |
| SCHEMBL28030473 | 0.73 | TSHR (0.66) | — | |
| SCHEMBL29633582 | 0.73 | KDM4E (0.51) | CREBBP | |
| SCHEMBL1501800 | 0.73 | S1PR1 (0.50) | CREBBPS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | ROCK2 1096/4885ROCK1 393/4885CREBBP 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.