Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.35 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333037 | 0.97 | REN (0.38) | RENALDH1A1AVPR1AF10HSD17B10 | |
| SCHEMBL7339328 | 0.92 | REN (0.43) | REN | |
| SCHEMBL7332487 | 0.92 | REN (0.42) | RENALDH1A1F10HSPA1AHSPA5 | |
| SCHEMBL7341341 | 0.90 | ALDH1A1 (0.36) | RENALDH1A1F10HSPA1AHSPA5 | |
| SCHEMBL7332191 | 0.87 | REN (0.35) | RENALDH1A1F10HSPA1AHSPA5 | |
| SCHEMBL7338969 | 0.84 | REN (0.39) | RENAVPR1AHSD17B10AVPR1BPLG | |
| SCHEMBL7331419 | 0.84 | AVPR1A (0.39) | ALDH1A1AVPR1AHSD17B10AVPR1BPLG | |
| SCHEMBL7330956 | 0.84 | REN (0.46) | RENALDH1A1F10HSD17B10F2 | |
| SCHEMBL7337437 | 0.82 | AVPR1A (0.40) | RENAVPR1AHSD17B10AVPR1BPLG | |
| SCHEMBL7337448 | 0.81 | REN (0.39) | RENAVPR1AHSD17B10AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |