Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 5/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330659 | 0.97 | REN (0.46) | RENCTSSF10OPRL1HSD17B10 | |
| SCHEMBL7337422 | 0.92 | REN (0.40) | RENCTSSF10OPRL1F2 | |
| SCHEMBL7338907 | 0.92 | KMT2A (0.41) | RENCTSSF10OPRL1F2 | |
| SCHEMBL7333699 | 0.89 | REN (0.38) | RENCTSSF10OPRL1F2 | |
| SCHEMBL7339920 | 0.87 | REN (0.36) | RENCTSSF10OPRL1F2 | |
| SCHEMBL7336887 | 0.84 | REN (0.38) | RENF10HSD17B10F2PLG | |
| SCHEMBL7331301 | 0.84 | REN (0.45) | RENCTSSF10OPRL1HSD17B10 | |
| SCHEMBL7339498 | 0.84 | REN (0.38) | RENCTSSF10OPRL1HSD17B10 | |
| SCHEMBL7332856 | 0.83 | REN (0.38) | RENCTSSOPRL1HSD17B10MEN1 | |
| SCHEMBL7339105 | 0.82 | HSD17B10 (0.37) | RENCTSSHSD17B10KMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |