Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.42 |
| ▸ | EDNRB | P24530 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342754 | 0.94 | EDNRB (0.42) | EDNRAEDNRBMEN1KMT2ALMNA | |
| SCHEMBL7340189 | 0.92 | EDNRB (0.40) | EDNRAEDNRBKMT2AALDH1A1POLB | |
| SCHEMBL7827728 | 0.89 | EDNRB (0.42) | EDNRAEDNRBMEN1KMT2ALMNA | |
| SCHEMBL7342900 | 0.88 | ALDH1A1 (0.40) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL7334097 | 0.87 | HSD11B1 (0.49) | EDNRAKMT2ALMNAMAPTHTT | |
| SCHEMBL7338776 | 0.87 | EDNRA (0.41) | EDNRAEDNRBMEN1KMT2ALMNA | |
| SCHEMBL7333608 | 0.86 | CHRM5 (0.42) | EDNRAEDNRBKMT2ALMNAHTT | |
| SCHEMBL7337167 | 0.85 | HCRTR2 (0.41) | EDNRAEDNRBLMNAHTTSMN1; SMN2 | |
| SCHEMBL7826340 | 0.83 | EDNRB (0.42) | EDNRAEDNRBMEN1KMT2ALMNA | |
| SCHEMBL7341323 | 0.82 | HSD11B1 (0.49) | MAPTHTTALDH1A1TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |