Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.42 |
| ▸ | EDNRA | P25101 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826340 | 0.94 | EDNRB (0.42) | EDNRBEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7829083 | 0.92 | POLB (0.42) | EDNRBEDNRAKMT2ALMNA | |
| SCHEMBL7337195 | 0.89 | EDNRA (0.42) | EDNRBEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7824156 | 0.87 | ALDH1A1 (0.46) | EDNRAMEN1KMT2ALMNAMAPT | |
| SCHEMBL7824055 | 0.86 | POLB (0.42) | EDNRBEDNRAKMT2ALMNAHTT | |
| SCHEMBL7832196 | 0.83 | HSD11B1 (0.43) | LMNAMAPTHTTNPC1RAB9A | |
| SCHEMBL7342754 | 0.83 | EDNRB (0.42) | EDNRBEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7817130 | 0.82 | EDNRB (0.45) | EDNRBEDNRALMNAMAPTHTT | |
| SCHEMBL7828475 | 0.81 | EDNRA (0.40) | EDNRBEDNRAMEN1KMT2ANPC1 | |
| SCHEMBL7828479 | 0.80 | PDK2 (0.32) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |