Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.42 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | MMP8 | P22894 | 7/20 | 0.42 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343875 | 0.77 | POLB (0.44) | MMP9MMP2MMP8MMP13KMT2A | |
| SCHEMBL17294170 | 0.76 | MMP9 (0.46) | MMP9MMP2MMP8MMP13KMT2A | |
| SCHEMBL16865428 | 0.70 | MMP9 (0.56) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL5448618 | 0.68 | MMP9 (0.64) | MMP9MMP2MMP8MMP13KMT2A | |
| SCHEMBL13620016 | 0.65 | GAA (0.61) | KMT2AMEN1CYP3A4HTTALDH1A1 | |
| SCHEMBL60236 | 0.64 | MEN1 (0.65) | KMT2AMEN1POLBKDM4EMAPT | |
| SCHEMBL17549557 | 0.64 | MAPT (0.36) | MMP9MMP2MMP8MMP13KMT2A | |
| SCHEMBL16865403 | 0.63 | MMP9 (0.50) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL7475063 | 0.63 | MMP9 (0.50) | MMP9MMP2MMP8MMP13KMT2A | |
| SCHEMBL11276893 | 0.63 | MMP9 (0.50) | MMP9MMP2MMP8MMP13CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242455-B1 | INHIBITING A MATRIX METALLOPROTEASE ASSOCIATED DISEASE | ROCHE DIAGNOSTICS GMBH (DE) | 2001-06-05 | — | — | US | claimed |
| US-6242455-B1 | INHIBITING A MATRIX METALLOPROTEASE ASSOCIATED DISEASE | ROCHE DIAGNOSTICS GMBH (DE) | 2001-06-05 | — | — | US | disclosed |
| EP-0991626-A2 | PYRIMIDIN-2,4,6-TRION DERIVATIVES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998058915-A2 | PYRIMIDIN-2,4,6-TRION DERIVATIVES AND THEIR USE AS METALLOPROTEASE-INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1998-12-30 | — | — | WO | disclosed |